Electrodeposition of Zn-Al-Layered Double Hydroxides With Interlayer Modification by Ibuprofen as Fiber Coating for Solid Phase Microextraction of Nonsteroidal Anti-Inflammatory Drugs
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View abstract on PubMed
Summary
This summary is machine-generated.This study developed a novel method using modified Zn-Al layered double hydroxides for efficient extraction of acetylsalicylic acid and naproxen from biological samples. The technique offers high sensitivity and accuracy for pharmaceutical analysis.
Area Of Science
- Analytical Chemistry
- Materials Science
Background
- Layered double hydroxides (LDHs) are versatile materials for adsorption and separation.
- Developing efficient methods for pharmaceutical analysis in biological matrices is crucial.
Purpose Of The Study
- To develop and optimize an in situ electrodeposition method for Zn-Al-LDHs on graphite substrates.
- To investigate the use of ibuprofen-modified Zn-Al-LDHs for extracting acetylsalicylic acid and naproxen.
- To evaluate the performance of the developed method for analyzing target analytes in real biological samples.
Main Methods
- In situ electrodeposition of Zn-Al-LDHs on pencil graphite substrates.
- Interlayer modification of LDHs with ibuprofen.
- Solid-phase microextraction (SPME) coupled with High-Performance Liquid Chromatography-UV (HPLC-UV).
- Experimental design (Plackett-Burman Design and Box-Behnken Design) for optimization.
Main Results
- Optimal conditions yielded low limits of detection (0.33-0.64 µg L⁻¹) and quantification (1.1-2.1 µg L⁻¹).
- A wide linear dynamic range (1-100 µg L⁻¹) with high correlation coefficients (r² > 0.9934) was achieved.
- Intra-day relative standard deviations were below 6.80%, and relative recoveries ranged from 90% to 109%.
Conclusions
- The ibuprofen-modified Zn-Al-LDH composite demonstrates excellent performance for preconcentration and extraction.
- The SPME-HPLC-UV method is suitable for the accurate determination of acetylsalicylic acid and naproxen in biological samples.
- The developed method offers a sensitive and reliable approach for pharmaceutical analysis.
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