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Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

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Ultra-High Frequency Spinal Nerve Neuromodulation for Improving Bladder Continence: Implications for Overactive

Bor-Shing Lin¹, Nurida Khasanah², Chun-Ying Cai³

¹Department of Computer Science and Information Engineering, National Taipei University, New Taipei City, Taiwan.

Neuromodulation : Journal of the International Neuromodulation Society

|November 6, 2024

Summary

Ultrahigh frequency (UHF) electrical stimulation of the L6 nerve root effectively suppressed bladder overactivity in rats. This neuromodulation technique offers a promising new approach for treating overactive bladder conditions.

Keywords:

Electrical stimulation neuromodulation overactive bladder spinal nerve ultrahigh frequency stimulation

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Area of Science:

Neuroscience
Urology
Biomedical Engineering

Background:

Ultrahigh frequencies (UHF) demonstrate selective sensory pathway suppression with rapid onset and prolonged effects.
Limited research exists on UHF electrical stimulation for overactive bladder (OAB) treatment.
The L6 nerve root's role in bladder control warrants investigation for neuromodulation.

Purpose of the Study:

To evaluate the efficacy of UHF electrical stimulation targeting the L6 nerve root in inhibiting bladder overactivity.
To assess the impact of UHF stimulation on key bladder function parameters.

Main Methods:

Female Sprague-Dawley rats underwent induced bladder overactivity using acetic acid infusion.
UHF electrical stimulation (500 kHz, 20 mA, 5 min) was applied to the L6 nerve root in the experimental group.
Cystometrography recorded intravesical pressure, measuring volume threshold (VT) and intercontraction interval (ICI).

Main Results:

Acetic acid successfully induced bladder overactivity, decreasing median VT and ICI.
UHF stimulation significantly increased median VT and ICI, counteracting the induced overactivity.
These inhibitory effects persisted for at least two hours, with significant differences observed between UHF and sham groups (p < 0.05).

Conclusions:

UHF stimulation of the L6 spinal nerve root shows potential for suppressing bladder overactivity.
This technique represents a viable alternative neuromodulation strategy for OAB.
The L6 nerve root serves as a potential target for UHF neuromodulation, analogous to human sacral nerve roots.