Exercise training to preserve vitality capacity in ageing
Raymond Jones1,2, Taylor L Taylor2,3, Robert T Mankowski1,2
1Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Experimental Physiology
|November 6, 2024
Summary
As people age, vitality capacity (VC) declines. Regular exercise can help maintain or improve VC components, supporting healthy ageing and addressing global health challenges.
Area of Science:
- Gerontology and Exercise Physiology
- Biomedical Sciences and Healthy Ageing
Background:
- Ageing is a significant global health concern, with a projected increase in the elderly population.
- Intrinsic Capacity (IC) serves as a measure of healthy ageing, encompassing physical and mental capabilities.
- Vitality Capacity (VC) is a key component of IC, crucial for maintaining function in older adults.
Purpose of the Study:
- To review the role of exercise in preserving Vitality Capacity (VC) in ageing populations.
- To explore the physiological domains of VC affected by ageing and exercise.
- To identify outcome measures and future research directions for VC and healthy ageing.
Main Methods:
- Literature review focusing on exercise interventions and their impact on VC components.
- Analysis of physiological domains including energy metabolism, neuromuscular function, immune response, mitochondrial function, and epigenetic ageing.
- Examination of potential outcome measures for assessing VC domains.
Main Results:
- Ageing leads to multifaceted deficits across various VC components.
- Exercise demonstrates potential to induce physiological adaptations beneficial for VC.
- Specific physiological domains of VC, such as mitochondrial function and methylation clock, are discussed in relation to exercise.
Conclusions:
- Ageing presents complex challenges to maintaining Vitality Capacity (VC).
- Regular physical activity is a viable strategy to mitigate age-related declines in VC.
- Exercise interventions can positively influence physiological markers of healthy ageing and improve VC status.
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