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Updated: Jun 8, 2025
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Published on: August 3, 2018
ADTGP: correcting single-cell antibody sequencing data using Gaussian process regression
Alex C H Liu1,2, Steven M Chan1,2
1Princess Margaret Cancer Centre, Toronto, Ontario, M5G 1L7, Canada.
Summary:
We present ADTGP, an R package that uses Gaussian process regression to correct droplet-specific technical noise in single-cell protein sequencing data. ADTGP improves the interpretability of the data by modeling the distribution of protein expression, conditioned on equal isotype control counts across cells. ADTGP is written in R and needs only the protein raw counts, isotype control raw counts, and a design matrix to run.
Availability And Implementation:
ADTGP can be installed from https://github.com/northNomad/ADTGP. It depends on Stan and the R package 'cmdstanr'.
