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A Polyphenol Decorated Triplex Hybrid Biomaterial: Structure-Function, Release Profiles, Sorption, and Antipathogenic

Mariam Mir¹, Lee D Wilson¹

¹Department of Chemistry, University of Saskatchewan, 110 Science Place, Thorvaldson Building, Saskatoon, Saskatchewan S7N 5C9, Canada.

ACS Applied Bio Materials

|November 6, 2024

Summary

Researchers developed a novel triplex hybrid biomaterial (THB) from flax, chitosan, and tannic acid. This unique material exhibits controlled release, high solvent uptake, and potent antimicrobial activity, paving the way for environmental and biomedical uses.

Keywords:

antipathogen activity hierarchal structure hybrid biomaterial polyphenols tannic acid-chitosan-fiber biocomposite

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Area of Science:

Materials Science
Biomaterials Engineering
Polymer Chemistry

Background:

Development of advanced hybrid biomaterials is crucial for environmental remediation and biomedical applications.
Flax, chitosan, and tannic acid offer unique properties for creating functional biomaterials.

Purpose of the Study:

To synthesize and characterize a novel hierarchal triplex hybrid biomaterial (THB) using a facile dip-coating method.
To investigate the physicochemical properties, release kinetics, solvent uptake, and antipathogenic activity of the THB.

Main Methods:

Nonwoven alkali-modified flax substrates were coated with chitosan and tannic acid via dip-coating.
Physicochemical properties were characterized using IR, Raman, NMR, XRD, and SEM.
Polyphenol release kinetics, solvent uptake, and antimicrobial activity were evaluated.

Main Results:

The THB exhibited a unique hierarchal porous structure and semicrystalline nature.
Polyphenol release followed the Korsmeyer-Peppas model, indicating Fickian diffusion.
The THB demonstrated significant solvent uptake (up to 4 g/g) and 95% pathogen elimination.

Conclusions:

The facile dip-coating strategy yields a unique hierarchal biomaterial with synergistic properties.
The THB shows promise as a responsive adsorbent for environmental remediation and biomedical applications.
This work presents the first example of such a hierarchal biomaterial for diverse applications.