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Related Experiment Videos

New ideas about self-tolerance and auto-immunity.

E Clark, P Lake, N A Mitchison

    Haematologia
    |January 1, 1978
    PubMed
    Summary
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    Self-tolerance in B cell development is primarily established through clonal deletion, particularly during the sensitive "baby B cell" stage. Evidence supports this, though immunological silence remains a consideration.

    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • B cell ontogeny research advances understanding of self-tolerance.
    • Clonal deletion is a principal mechanism for generating self-tolerance.
    • B cells exhibit heightened sensitivity during the
    • baby B cell
    • stage.

    Purpose of the Study:

    • To explore the role of clonal deletion in B cell development and self-tolerance.
    • To investigate the implications of receptor cross-linking sensitivity in immature B cells.
    • To reconcile evidence for clonal deletion with the concept of immunological silence.

    Main Methods:

    • Analysis of B cell ontogeny.
    • Studies on the maintenance of liver differentiation alloantigen F.

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  • Theoretical considerations based on dual recognition theory of T cell receptors.

    • Main Results:

    • Evidence strengthens the theory that self-tolerance is mainly generated by clonal deletion.
    • The
    • baby B cell
    • stage is crucial due to receptor cross-linking susceptibility.
    • Studies on alloantigen F provide further support for clonal deletion.

    Conclusions:

    • Clonal deletion is a key mechanism in establishing B cell self-tolerance.
    • The
    • baby B cell
    • stage is a critical window for deletion.
    • The concept of immunological silence persists, particularly concerning T helper cell recognition of certain cell surface molecules.