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Related Experiment Video

Updated: Jun 8, 2025

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Bioinspired injectable hydrogels for bone regeneration.

Xuan Tang1, Fengjin Zhou2, Sicheng Wang3

  • 1Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai 200444, China; National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai 200444, China.

Journal of Advanced Research
|November 6, 2024
PubMed
Summary
This summary is machine-generated.

Bioinspired injectable hydrogels offer a minimally invasive solution for bone and cartilage regeneration, overcoming limitations of traditional therapies. These advanced materials show promise for clinical applications in treating tissue defects.

Keywords:
Advanced biotechnologyBioinspiredBone regenerationCartilage regenerationInjectable hydrogels

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Bone and cartilage defects pose significant clinical challenges, with conventional treatments often yielding suboptimal results.
  • There is a critical need for innovative therapeutic strategies to address irreversible tissue damage.
  • Injectable hydrogels are emerging as promising biomaterial-based solutions due to their minimally invasive nature and controlled release capabilities.

Purpose of the Study:

  • To systematically review the synthesis and bioinspired design strategies of injectable hydrogels for bone and cartilage regeneration.
  • To explore the applications of these hydrogels in various bone and cartilage disease models.
  • To highlight the potential of bioinspired injectable hydrogels for future clinical translation.

Main Methods:

  • Systematic review of literature on injectable hydrogel synthesis.
  • Analysis of bioinspired design approaches, including microenvironment, structural, compositional, and bioactive component strategies.
  • Evaluation of hydrogel applications in preclinical bone and cartilage regeneration models.

Main Results:

  • Injectable hydrogels, particularly those employing bioinspired design, demonstrate significant potential for promoting bone and cartilage regeneration.
  • Bioinspired strategies enhance the efficacy of hydrogels by mimicking natural tissue environments and functions.
  • These hydrogels offer advantages such as minimal invasiveness, shape adaptability, and controlled release.

Conclusions:

  • Bioinspired injectable hydrogels represent a promising and feasible approach for advancing bone and cartilage regeneration therapies.
  • These materials provide a foundation for future clinical applications in treating degenerative diseases and injuries.
  • Future directions include leveraging artificial intelligence (AI) for hydrogel screening and organoid construction.