[High expression of CREM is associated with poor prognosis in gastric cancer patients]

M Ye ^1,2, H Wu ², Y Mei ²

⁰School of Medicine, South China University of Technology, Guangzhou 510006, China.

Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University +

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November 6, 2024

View abstract on PubMed

Summary

High expression of CREM (cAMP-responsive element modulator) in gastric cancer (GC) correlates with poor patient prognosis. This suggests CREM could be a valuable indicator for predicting GC outcomes.

Area Of Science

Molecular oncology
Cancer genomics
Biomarker discovery

Context

Gastric cancer (GC) remains a significant global health challenge.
Identifying reliable prognostic markers is crucial for improving patient outcomes.
The role of CREM in GC pathogenesis is not well understood.

Purpose

To investigate the expression levels of CREM in GC tissues.
To determine the correlation between CREM expression and GC patient prognosis.
To explore the potential molecular pathways influenced by CREM in GC.

Summary

CREM mRNA and protein were found to be significantly upregulated in GC tissues compared to adjacent normal tissues.
High CREM expression was strongly associated with advanced T-stage and N-stage, and correlated with poorer overall survival in GC patients.
Functional enrichment analysis indicated that CREM may promote GC progression via the cell adhesion signaling pathway.

Impact

This study identifies CREM as a potential prognostic biomarker for gastric cancer.
Understanding CREM's role in cell adhesion signaling may reveal new therapeutic targets.
Findings contribute to the molecular understanding of GC development and progression.

Keywords:

CREM bioinformatics gastric cancer immunohistochemistry prognosis