[A multi-constraint optimal puncture path planning algorithm for percutaneous interventional radiofrequency thermal...

To minimize variations in treatment outcomes of L5/S1 percutaneous intervertebral radiofrequency thermocoagulation (PIRFT) arising from physician proficiency and achieve precise quantitative risk assessment of the puncture paths.

We used a self-developed deep neural network DWT-UNet for automatic segmentation of the magnetic resonance (MR) images of the L5/S1 segments into 7 key structures: L5, S1, Ilium, Disc, N5, Dura mater, and Skin, based on which a needle insertion path planning environment was modeled. Six hard constraints and 6 soft constraints were proposed based on clinical criteria for needle insertion, and the physician's experience was quantified into weights using the analytic hierarchy process and incorporated into the risk function for needle insertion paths to enhance individual case adaptability. By leveraging the proposed skin entry point sampling sub-algorithm and Kambin's triangle projection area sub-algorithm in conjunction with the analytic hierarchy process, and employing various technologies such as ray tracing, CPU multi-threading, and GPU parallel computing, a puncture path was calculated that not only met clinical hard constraints but also optimized the overall soft constraints.

A surgical team conducted a subjective evaluation of the 21 needle puncture paths planned by the algorithm, and all the paths met the clinical requirements, with 95.24% of them rated excellent or good. Compared with the physician's planning results, the plans generated by the algorithm showed inferior D_Ilium, D_S1, and Depth (P < 0.05) but much better D_Dura, D_L5, D_N5, and A_Kambin (P < 0.05). In the 21 cases, the planning time of the algorithm averaged 7.97±3.73 s, much shorter than that by the physicians (typically beyond 10 min).

The multi-constraint optimal puncture path planning algorithm offers an efficient automated solution for PIRFT of the L5/S1 segments with great potentials for clinical application.