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Published on: December 8, 2023
[Gluteal tendinitis and primary coxarthrosis may lead to iliotibial band syndrome: a Mendelian randomization study]
1Department of Orthopedics and Traumatology, Shenzhen Bao'an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen 518000, China.
Objective:
To analyze the causal relationship of gluteal tendinitis and primary coxarthrosis with the occurrence of iliotibial band syndrome using Mendelian randomization.
Methods:
The GWAS data of gluteal tendinitis, primary coxarthrosis and iliotibial band syndrome were screened for high correlation single-nucleotide polymorphisms (SNPs). Mendelian randomization analysis was performed using random-effects inverse variance weighting (IVW), MR-Egger regression, and weighted median method to determine whether gluteal tendinitis and primary coxarthrosis were causally related with iliotibial band syndrome. Heterogeneity test, multiple validity test and sensitivity analysis, and clinical data analysis were used to verify the reliability of the results.
Results:
Both gluteal tendinitis [IVW: OR(95% CI)=1.32 (1.03-1.68), P=0.026] and primary coxarthrosis [IVW: OR (95% CI)=1.40 (1.06-1.84), P=0.017] was positively correlated with iliotibial band syndrome.
Conclusion:
Gluteal tendinitis and primary coxarthrosis may increase the risk of iliotibial band syndrome.
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