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Plasma High-Mobility Group Box-1 and Galectin-9 in Patients with Trauma and Their Prognostic Potentials
Toshiro Niki1, Haorile Chagan-Yasutan2,3, Daisuke Furushima4,5
1Department of Immunology, Faculty of Medicine, Kagawa University.
The Tohoku Journal of Experimental Medicine
|November 6, 2024
Summary
High-mobility group box-1 (HMGB-1) shows prognostic potential in trauma patients, unlike galectin-9 (Gal-9). HMGB-1 may serve as a valuable blood biomarker for predicting trauma outcomes.
Area of Science:
- Biochemistry
- Immunology
- Trauma Research
Background:
- Damage-associated molecular patterns (DAMPs) are endogenous molecules released from damaged tissues.
- DAMPs are implicated in inflammatory responses and disrupted immune homeostasis following traumatic injuries.
Purpose of the Study:
- To examine plasma levels of galectin-9 (Gal-9) and high-mobility group box-1 (HMGB-1) in trauma patients.
- To assess the prognostic potential of these DAMPs in discriminating between survived and deceased patients.
Main Methods:
- Measurement of plasma Gal-9 and HMGB-1 levels at admission and over a 7-day period in trauma patients.
- Correlation analysis between DAMP concentrations and prognostic parameters.
- Receiver-operating characteristic (ROC) curve analysis for prognostic discrimination.
Main Results:
- Gal-9 levels were high at admission and normalized within 48 hours.
- HMGB-1 levels peaked at admission, remained elevated for 7 days, and correlated with 6 prognostic parameters.
- HMGB-1, unlike Gal-9, could discriminate between survived and deceased patients, showing moderate prognostic potential via ROC analysis.
Conclusions:
- HMGB-1 demonstrates significant prognostic potential as a blood biomarker in trauma.
- HMGB-1 may be valuable for predicting trauma outcomes, potentially in conjunction with other biomarkers.
