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Updated: Jun 8, 2025

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
Published on: June 4, 2020
Hippocampus supports long-term maintenance of language representations: Evidence of impaired collocation knowledge in
Natalie V Covington1, Melissa C Duff2
1Department of Speech Language Hearing Sciences, University of Minnesota, Minneapolis, MN, USA; Courage Kenny Rehabilitation Institute, Allina Health, Minneapolis, MN, USA; Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Minneapolis, MN, USA.
Abstract:
Traditional systems consolidation theories of memory suggest that the role of the hippocampus in maintaining memory representations diminishes over time, with learned information eventually becoming fully independent of the hippocampus. Knowledge of collocations in one's native (L1) language are acquired during development and are solidly acquired by adulthood. Remote semantic knowledge of collocations might therefore be expected to be resistant to hippocampal pathology. Patients with hippocampal damage and severe anterograde amnesia completed two tasks testing English collocation knowledge originally designed for use with English language learners. Patients with hippocampal damage demonstrated impairments in recognition of common English collocations, despite a lifetime of language experience (including postsecondary education) prior to sustaining this damage. These results suggest the hippocampus contributes to the long-term maintenance of linguistic representations and provides a challenge to traditional consolidation views of memory and an extension of newer theories to include a role for the hippocampus in maintaining semantic memory.
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