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Updated: Jun 8, 2025

A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats

A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats

Published on: November 7, 2017

Multifunctional Neural Probes Enable Bidirectional Electrical, Optical, and Chemical Recording and Stimulation In

Nicolette Driscoll¹, Marc-Joseph Antonini¹, Taylor M Cannon¹

¹Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

Advanced Materials (Deerfield Beach, Fla.)

|November 7, 2024

Summary

Researchers developed novel multimodal neural fibers for simultaneous recording, stimulation, and chemical analysis in the brain. These advanced tools integrate electrical, optical, and chemical sensing for comprehensive neuroscience research.

Keywords:

fast‐scan cyclic voltammetry fiber photometry fiber‐based interface multifunctional neural probe neuromodulation

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Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents

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Published on: March 4, 2012

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Last Updated: Jun 8, 2025

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Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents

Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents

Published on: March 4, 2012

Area of Science:

Neuroscience
Biomaterials Science
Neuroengineering

Background:

Understanding brain function requires tools to record and modulate neuronal activity.
Current methods often focus on single modalities (electrical, optical, chemical), limiting comprehensive analysis.
Integrating multiple recording and stimulation techniques into a single platform is a significant challenge in neuroscience.

Purpose of the Study:

To develop a versatile fiber platform enabling simultaneous neural recording, electrical stimulation, optogenetics, fiber photometry, drug/gene delivery, and neurotransmitter voltammetry.
To create a tool compatible with magnetic resonance imaging (MRI) for concurrent whole-brain monitoring and stimulation.
To demonstrate the utility of this multimodal fiber in studying neurochemical and neurophysiological processes in vivo.

Main Methods:

Materials selection and convergence fiber drawing to integrate diverse functionalities within individual fibers.
Utilizing polymers and non-magnetic carbon-based conductors for fiber fabrication.
Demonstration in mouse models, specifically targeting the mesolimbic reward pathway (ventral tegmental area and nucleus accumbens).

Main Results:

Successful integration of neural recording, electrical stimulation, optogenetics, fiber photometry, drug/gene delivery, and voltammetric neurotransmitter detection in single fibers.
Demonstrated compatibility with MRI for concurrent whole-brain monitoring and stimulation.
Characterized neurophysiological effects of a stimulant drug in the mesolimbic reward pathway.

Conclusions:

The developed multimodal neural fibers offer a powerful, integrated platform for advanced neuroscience research.
This technology facilitates simultaneous probing of electrical, optical, and chemical signaling across multiple brain regions.
The fibers hold significant potential for both mechanistic and translational studies in neuroscience and related fields.