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Updated: Jun 8, 2025
10:21
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
389
Sjögren's Syndrome and Ankylosing Spondylitis Association: A Case-Based Review
Maroua Slouma1,2, Takwa Mehmli1,2, Emna Hannech1,2
1Department of Rheumatology, Military Hospital, Tunis, Tunisia.
Current Rheumatology Reviews
|November 7, 2024
Summary
Sjögren's syndrome (SS) is rare in ankylosing spondylitis (AS) but should be considered, especially with diffuse interstitial lung disease. This association may indicate a shared pathway and requires therapeutic consideration.
Area of Science:
- Rheumatology
- Pulmonology
- Autoimmune Diseases
Background:
- Diffuse interstitial lung disease (ILD) is uncommon in ankylosing spondylitis (AS).
- This study reviews the association between AS and Sjögren's syndrome (SS).
- A case of SS revealed by ILD in an AS patient on TNF inhibitors is presented.
Purpose of the Study:
- To systematically review the association between ankylosing spondylitis and Sjögren's syndrome.
- To highlight the importance of considering SS in AS patients, particularly those with ILD.
Main Methods:
- Systematic review adhering to PRISMA guidelines.
- Searched MEDLINE and SCOPUS databases for case reports and series on AS and SS.
- Included a novel case of SS with ILD in an AS patient.
Main Results:
- Sixty-three patients (16 males, 47 females; mean age 49.2 years) were analyzed.
- Sjögren's syndrome was diagnosed after AS in 62% of cases.
- Only the presented case exhibited interstitial lung disease; sicca symptoms were universal.
Conclusions:
- Sjögren's syndrome is an uncommon comorbidity in ankylosing spondylitis.
- The association suggests a potential pathogenetic link requiring clinical consideration.
- Recognizing this link is crucial for appropriate management in AS patients with diffuse ILD.
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