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Updated: Jun 8, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Paired electrocatalysis enabled oxidative coupling of styrenes with alkyl radicals
Dong Li1,2, Ling Zhang1, Daixi Li3,4
1Frontiers Science Center for Transformative Molecules (FSCTM), Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, ZhangJiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China. taoshen@sjtu.edu.cn.
Abstract:
A paired electrocatalysis strategy for intermolecular oxidative cross-dehydrocoupling between styrenes and ethers or p-methylphenol derivatives using ketone as a mild oxidant is described. This approach enables the generation of Csp3 carbon-centered radicals through anodic oxidation, followed by reductive coupling of ketones at the cathode, ultimately yielding valuable oxidative alkylation products.
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