Inflammation, tertiary lymphoid structures, and lung cancer: a bibliometric analysis

Area of Science:

• Oncology
• Immunology
• Bibliometrics

Background:

• The relationship between inflammation and lung cancer is complex and not fully understood.
• Tertiary Lymphoid Structures (TLS) play a role in the immune response within the tumor microenvironment.
• Clinical understanding of TLS in lung cancer prognosis and therapy is needed.

Purpose of the Study:

• To conduct a bibliometric analysis of lung cancer and inflammation research.
• To explore the correlations between lung cancer, inflammation, and TLS.
• To identify publication trends, collaborative networks, and emerging research directions.

Main Methods:

• Bibliometric analysis of 1,284 studies from 2013-2023.
• Data sourced from Web of Science Core Collection.
• Inclusion criteria: English, original articles/reviews; exclusion criteria applied.

Main Results:

• Publication trend shows a significant increase since 2013.
• Research is international, with China leading contributions.
• Key authors, journals, and evolving research themes identified, emphasizing TLS's role.

Conclusions:

• Inflammation is crucial in lung cancer progression.
• TLS are emerging indicators of adaptive immunity in the tumor microenvironment.
• Future research should focus on TLS mechanisms and clinical validation for therapeutic strategies.