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Infantile bacterial meningitis combined with sepsis caused by Streptococcus gallolyticus subspecies pasteurianus: A

Dan Zou1, Fen Li2, Shu-Li Jiao1

  • 1Department of Pediatrics, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang 621000, Sichuan Province, China.

World Journal of Clinical Cases
|November 7, 2024
PubMed
Abstract

Insights

This case highlights Streptococcus gallolyticus subspecies pasteurianus (SGSP) infant meningitis and sepsis, often overlooked in screenings. Prompt diagnosis and sensitive antibiotic therapy are crucial for a favorable outcome in infants.

Area of Science:

  • Pediatric Infectious Diseases
  • Bacteriology
  • Neonatal Care

Background:

  • Streptococcus gallolyticus subspecies pasteurianus (SGSP) is a rare cause of infant sepsis and meningitis.
  • SGSP is often missed due to not being part of routine group B streptococcal screenings.

Observation:

  • A 45-day-old infant presented with fever, seizures, and laboratory findings indicative of infection.
  • Blood and cerebrospinal fluid (CSF) cultures identified SGSP as the causative agent.
  • The infant also had bronchopneumonia caused by multidrug-resistant Staphylococcus aureus (MRSA).

Findings:

  • The infant received ceftriaxone and vancomycin, showing sensitivity to multiple antibiotics.
  • Treatment led to normalization of blood and CSF parameters within 12 days.
  • Cranial CT revealed no complications, and the infant had no neurological sequelae at follow-up.

Implications:

  • Early identification of SGSP through blood and CSF cultures is vital for infant meningitis and sepsis.
  • Tailoring antibiotic therapy based on sensitivity testing ensures effective treatment and good prognosis.
  • Co-infections, like MRSA pneumonia, require concurrent management for optimal patient recovery.
Keywords:
Bacterial meningitisBronchopneumoniaCase reportInfantMultidrug-resistant Staphylococcus aureusRare pathogenSepsisStreptococcus gallolyticus subspecies pasteurianus

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