Related Experiment Video

Updated: Jun 8, 2025

Purification of Viral DNA for the Identification of Associated Viral and Cellular Proteins
08:26

Purification of Viral DNA for the Identification of Associated Viral and Cellular Proteins

Published on: August 31, 2017

13.6K

Multiple functions of the herpesvirus UL14 gene product in viral infection

Jieyu Wan1,2,3,4,5, Mingshu Wang1,2,3,4,5, Anchun Cheng1,2,3,4,5

  • 1Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, China.

Frontiers in Microbiology
|November 7, 2024
PubMed

Insights

The herpesvirus UL14 protein (pUL14) is crucial for viral replication, regulating gene expression, particle assembly, and release. Understanding pUL14

Area of Science:

  • Virology
  • Molecular Biology
  • Cellular Biology

Background:

  • Herpesviruses are complex double-stranded DNA viruses.
  • The UL14 gene encodes protein UL14 (pUL14), a key viral component.
  • pUL14 exhibits diverse subcellular localizations and functions.

Purpose of the Study:

  • To review the multifaceted roles of pUL14 in the herpesvirus life cycle.
  • To explore pUL14's impact on viral gene expression and particle formation.
  • To identify new research avenues for pUL14's function in viral infections.

Main Methods:

  • Literature review of existing studies on herpesvirus UL14.
  • Analysis of pUL14's known functions in transcription, localization, and viral release.
  • Synthesis of current knowledge regarding pUL14's cellular homeostasis and apoptosis roles.

Main Results:

  • pUL14 regulates immediate-early gene transcription and expression.
  • pUL14 influences the localization of capsid and DNA packaging proteins.
  • pUL14 is involved in viral secondary envelopment and particle release.
  • pUL14 contributes to maintaining cellular homeostasis and preventing apoptosis.

Conclusions:

  • pUL114 is a critical multifunctional protein in the herpesvirus life cycle.
  • Further research into pUL14's mechanisms can reveal novel antiviral strategies.
  • Understanding pUL14's interactions offers insights into viral pathogenesis and cellular defense.
Keywords:
herpesviruspUL14tegument proteinsviral infectionviral replication

More Related Videos

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

11.0K
Temporal Analysis of the Nuclear-to-cytoplasmic Translocation of a Herpes Simplex Virus 1 Protein by Immunofluorescent Confocal Microscopy06:40

Temporal Analysis of the Nuclear-to-cytoplasmic Translocation of a Herpes Simplex Virus 1 Protein by Immunofluorescent Confocal Microscopy

Published on: November 4, 2018

6.2K

Related Concept Videos

Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
753
Leaky Scanning02:28

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.1K
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
3
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.7K
Retroviruses02:33

Retroviruses

Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
12.2K
Viral Structure00:56

Viral Structure

Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
61.8K