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  11. A Critical Appraisal Of Intraoperative Frozen Section Analysis Of Ovarian Tumors: A 3-year Review Of Accuracy And Clinicopathological Correlation At A Tertiary Care Center.

A Critical Appraisal of Intraoperative Frozen Section Analysis of Ovarian Tumors: A 3-Year Review of Accuracy and Clinicopathological Correlation at a Tertiary Care Center.

Mukta Pujani1, Sujata Raychaudhuri1, Kanika Singh1

  • 1Department of Pathology, ESIC Medical College and Hospital, Faridabad, Haryana, India.

Journal of Microscopy and Ultrastructure
|November 7, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Intraoperative frozen section (IFS) accurately diagnoses ovarian tumors, aiding surgical decisions when screening is limited. This study confirms IFS as a reliable tool for evaluating ovarian masses, with high sensitivity and specificity.

Area of Science:

  • Gynecologic Oncology
  • Surgical Pathology
  • Diagnostic Accuracy

Background:

  • Ovarian cancer lacks effective screening methods, making intraoperative diagnosis crucial.
  • Intraoperative frozen section (IFS) is vital for guiding surgical management of ovarian masses.
  • Histopathology is the gold standard for diagnosing ovarian tumors.

Purpose of the Study:

  • To evaluate the diagnostic accuracy of intraoperative frozen section (IFS) for ovarian tumors.
  • To compare IFS diagnoses with final histopathological findings.
  • To assess the role of clinicopathological parameters in predicting ovarian malignancy.

Main Methods:

  • Prospective analysis of 52 ovarian mass cases undergoing IFS over 3 years.
  • Comparison of frozen section reports with permanent paraffin section diagnoses.
Keywords:
Diagnostic accuracyfrozen sectionintraoperative assessmentovarian cancer

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  • Calculation of sensitivity, specificity, PPV, NPV, and diagnostic accuracy for IFS.

    • Main Results:

    • The study included 42 benign, 3 borderline, and 7 malignant ovarian tumors.
    • IFS demonstrated high diagnostic accuracy: 90% sensitivity, 97% specificity, 90% PPV, 97% NPV, and 94% overall accuracy.
    • CA-125 levels and menopausal status were significant predictors of malignancy.

    Conclusions:

    • Frozen section provides timely pathological examination, facilitating surgeon-pathologist communication.
    • Despite a small sample size, IFS is an effective tool for intraoperative evaluation of ovarian masses.
    • Judicious use of IFS by pathologists and surgeons maximizes its diagnostic advantages for ovarian tumors.
    ovarian tumors