Prognostic value of neutrophil to lymphocyte ratio for patients with bladder cancer undergoing radical cystectomy: a systematic review and meta-analysis
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Summary
This summary is machine-generated.The neutrophil-to-lymphocyte ratio (NLR) is a significant predictor of survival in bladder cancer patients after radical cystectomy. Elevated NLR indicates a poorer prognosis, impacting overall survival and disease-free survival.
Area Of Science
- Oncology
- Immunology
- Urology
Background
- Radical cystectomy is a primary treatment for muscle-invasive bladder cancer.
- Identifying reliable prognostic markers is crucial for patient management and treatment stratification.
- The neutrophil-to-lymphocyte ratio (NLR) has emerged as a potential biomarker in various cancers.
Purpose Of The Study
- To evaluate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) for survival outcomes in bladder cancer patients undergoing radical cystectomy.
- To synthesize evidence from existing cohort studies through a meta-analysis.
Main Methods
- A systematic literature search was conducted across PubMed, Embase, Web of Science, and Cochrane databases up to April 2024.
- Included studies assessed the association between NLR and survival outcomes such as overall survival (OS), disease-free survival (DFS), relapse-free survival (RFS), cancer-specific survival (CSS), and progression-free survival (PFS).
- A meta-analysis of 15 cohort studies involving 8,448 patients was performed.
Main Results
- High NLR was significantly associated with shorter OS, CSS, DFS, and RFS compared to low NLR.
- No significant difference in progression-free survival (PFS) was observed between high and low NLR groups.
- Multivariate analysis confirmed NLR as an independent prognostic factor.
Conclusions
- The neutrophil-to-lymphocyte ratio (NLR) is an independent prognostic indicator for bladder cancer patients treated with radical cystectomy.
- Elevated NLR levels are linked to inferior survival outcomes.
- Further large-scale, prospective studies are recommended to confirm the prognostic role of NLR in bladder cancer.
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