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Related Concept Videos

Overview of Protein Metabolism01:21

Overview of Protein Metabolism

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Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
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Protein Folding Quality Check in the RER01:29

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ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...
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Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
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Inborn Errors of Metabolism01:20

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Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
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Protein Denaturation01:28

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The function of proteins depends on their native three-dimensional structure, which is dictated by the amino acid sequence of the specific protein. Folding of the polypeptide chain takes place under specific conditions that energetically favor the folded conformation. In contrast, protein denaturation occurs spontaneously under unfavorable conditions that disrupt the integrity of the folded conformation. Thus, the chemical and physical environment of a protein, such as significant changes in pH...
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Proteins: From Genes to Degradation02:11

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Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
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Updated: Jun 8, 2025

Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography
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Published on: December 1, 2023

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Protein quality malnutrition.

Mark J Manary1,2, Donna R Wegner1, Kenneth Maleta3

  • 1Department of Pediatrics, Washington University, St. Louis, MO, United States.

Frontiers in Nutrition
|November 7, 2024
PubMed
Summary
This summary is machine-generated.

Protein quality scores like PDCAAS and DIAAS do not fully predict recovery in malnourished children. Milk protein offers advantages over vegetable proteins for weight gain and recovery in these vulnerable populations.

Keywords:
DIAASPDCAASmalnutritionprotein metabolismprotein quality

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Area of Science:

  • Nutrition Science
  • Pediatric Malnutrition
  • Dietary Protein

Background:

  • Protein quality is assessed by amino acid composition, digestibility, and bioavailability.
  • Common scoring systems (PDCAAS, DIAAS) do not consider the protein's dietary source.
  • Malnourished children have altered amino acid metabolism and increased protein demands due to infection and growth needs.

Purpose of the Study:

  • To evaluate the predictive value of protein quality scores in moderately malnourished children.
  • To compare the efficacy of milk protein versus vegetable protein in recovery.

Main Methods:

  • Review of two large clinical feeding trials in moderately malnourished children.
  • Careful measurement of dietary protein quality parameters.
  • Assessment of weight gain and recovery as outcomes.

Main Results:

  • Protein quality scores alone were insufficient to reliably predict weight gain or recovery.
  • Milk protein consumption demonstrated clear benefits over vegetable-based proteins.
  • Individualized assessment beyond scoring systems is crucial for recovery.

Conclusions:

  • Dietary protein source significantly impacts recovery in malnourished children.
  • Current protein quality scoring systems may not fully capture nutritional needs in clinical settings.
  • Milk protein appears superior to vegetable protein for promoting recovery in this population.