The association between dietary consumption habits and psoriasis: a two-sample Mendelian randomization study

Area of Science:

• Dermatology
• Nutritional Science
• Genetic Epidemiology

Background:

• Psoriasis is a global chronic inflammatory skin disease.
• Dietary habits are suspected to influence psoriasis development.
• Causal links between diet and psoriasis require robust investigation.

Purpose of the Study:

• To determine the causal relationship between dietary consumption habits and psoriasis.
• Utilize the Mendelian Randomization (MR) approach for causal inference.
• Analyze 29 distinct dietary consumption habits in relation to psoriasis.

Main Methods:

• Obtained SNP data for 29 dietary habits and psoriasis from GWAS and FinnGen databases.
• Performed Mendelian Randomization analysis using R software.
• Employed Inverse Variance Weighted (IVW), Weighted Median Estimator (WME), and MR-Egger regression methods.

Main Results:

• Inverse Variance Weighted (IVW) analysis revealed a significant negative correlation between dried fruit consumption and psoriasis (OR: 0.065, 95% CI: 0.008-0.555, p=0.012).
• This indicates a protective effect of dried fruit intake against psoriasis.
• No other significant dietary associations were detailed in the provided abstract.

Conclusions:

• Dried fruit intake emerged as a significant protective factor against psoriasis.
• Increasing dried fruit consumption is clinically advisable for psoriasis patients.
• Dietary modification, specifically increased dried fruit intake, can serve as a complementary nutritional therapy.