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Cardio-Ankle Vascular Index: Test-Retest Reliability and Agreement in People With Stroke.

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The cardio-ankle vascular index (CAVI) shows good reliability for clinical use. Higher CAVI values correlate with fatigue and poorer sleep quality in stroke survivors, indicating its potential in stroke patient assessment.

Keywords:
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Area of Science:

  • Vascular physiology
  • Biomedical engineering
  • Clinical assessment

Background:

  • Arterial stiffness measurement is crucial for cardiovascular health assessment.
  • The cardio-ankle vascular index (CAVI) offers a more advanced method than traditional techniques.
  • Clinical adoption of CAVI has been limited despite scientific evidence.

Purpose of the Study:

  • To evaluate the test-retest reliability and agreement of CAVI measurements.
  • To investigate the correlation between CAVI, fatigue, and sleep quality.
  • To compare CAVI in stroke patients, differentiating between paretic and non-paretic sides and fatigue status.

Main Methods:

  • Sixty-seven participants were assessed using CAVI, Fatigue Assessment Scale, and Pittsburgh Sleep Quality Index.
  • Test-retest reliability was analyzed using correlation coefficients and Bland-Altman plots.
  • Standard error of measurement and minimal detectable change were calculated.

Main Results:

  • CAVI demonstrated good test-retest reliability (0.77–0.86) and agreement.
  • CAVI values correlated with fatigue and, on the paretic side, with sleep quality.
  • Paretic limb CAVI was higher than non-paretic limb CAVI; fatigued stroke survivors had elevated CAVI.

Conclusions:

  • CAVI exhibits robust test-retest reliability and measurement agreement, supporting its clinical utility.
  • CAVI is a potential biomarker for assessing arterial stiffness, fatigue, and sleep disturbances in stroke patients.
  • Findings suggest CAVI can differentiate between stroke-affected and unaffected sides and identify heightened vascular stiffness in fatigued individuals.