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Tryptophan-immunoadsorption plasmapheresis regulates polymorphonuclear-myeloid-derived suppressor cells and
Hanae Wakabayashi1, Noriyuki Hattori2, Akiyuki Uzawa3
1Department of Nephrology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Summary
Immunoadsorption plasmapheresis (IA) increases myeloid-derived suppressor cells (MDSCs) and anti-inflammatory cytokines, potentially improving outcomes in autoimmune neurological diseases like myasthenia gravis.
Area of Science:
- Neuroimmunology
- Immunology
- Medical Technology
Background:
- Immunoadsorption plasmapheresis (IA) exhibits immunomodulatory effects beyond autoantibody removal.
- Investigating IA's impact on myeloid-derived suppressor cells (MDSCs) is crucial for understanding autoimmune response regulation.
Purpose of the Study:
- To evaluate the effect of tryptophan-IA on the proportion of polymorphonuclear (PMN)-MDSCs.
- To assess the correlation between increased PMN-MDSCs and clinical efficacy in autoimmune neurological diseases.
Main Methods:
- Studied 21 patients with autoimmune neurological diseases and 8 healthy controls.
- Measured PMN-MDSCs and inflammatory mediators before and after tryptophan-IA.
- Assessed clinical efficacy using the Quantitative Myasthenia Gravis score.
Main Results:
- IA significantly increased PMN-MDSCs and levels of IL-10, MCP-1, and MIP-1β.
- A rise in PMN-MDSCs post-IA correlated with lower myasthenia gravis scores at discharge.
- Increased PMN-MDSCs (≥20% of PBMCs) predicted better clinical outcomes.
Conclusions:
- Tryptophan-IA modulates PMN-MDSCs and pro-inflammatory cytokines.
- This modulation may suppress autoimmune responses and reduce tissue damage in neuroimmunological disorders.
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