Effect of Dual-Site Non-Invasive Brain Stimulation on Upper-Limb Function After Stroke: A Systematic Review and...

Area of Science:

• Neuroscience
• Rehabilitation Medicine
• Clinical Trials

Background:

• Non-invasive brain stimulation (NIBS) is recognized for aiding upper limb motor recovery in stroke patients.
• Dual-site non-invasive brain stimulation (DS-NIBS) is an emerging technique for post-stroke rehabilitation.

Purpose of the Study:

• To evaluate the efficacy of DS-NIBS in enhancing upper extremity motor function following stroke.
• To compare the effectiveness of DS-NIBS against sham and single-site non-invasive brain stimulation (SS-NIBS).

Main Methods:

• A systematic literature search was performed adhering to PRISMA guidelines.
• Randomized controlled trials investigating DS-NIBS for post-stroke motor recovery were included.
• Data extraction and quality assessment were conducted by two independent reviewers.

Main Results:

• Ten studies were analyzed, indicating a significant positive effect of DS-NIBS on upper extremity motor function impairment.
• DS-NIBS demonstrated superior efficacy compared to sham and SS-NIBS.
• Dual-site transcranial magnetic stimulation (DS-TMS) appeared more effective than dual-site transcranial direct current stimulation (DS-tDCS).

Conclusions:

• DS-NIBS shows potential as an effective intervention for post-stroke upper extremity motor deficits.
• The overall efficacy of DS-NIBS remains inconclusive due to the limited number of studies.
• Further research is warranted to confirm the benefits and optimal application of DS-NIBS.