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Updated: Jun 8, 2025
Author Spotlight: Enhancing Upper Limb Rehabilitation in Stroke Patients Through Advanced Robotic and Neuromodulation Technologies
Published on: October 11, 2024
Effect of Dual-Site Non-Invasive Brain Stimulation on Upper-Limb Function After Stroke: A Systematic Review and
Meng Ren1,2, Jingjing Xu3, Wenjing Wang4
1RainbowFish Rehabilitation and Nursing School, Hangzhou Vocational and Technical College, Hangzhou, China.
Background:
Non-invasive brain stimulation (NIBS) has attracted significant attention as it has been proven to be effective in facilitating upper limb motor recovery in patients with stroke. This meta-analysis evaluates the efficacy of dual-site non-invasive brain stimulation (DS-NIBS) in improving upper extremity motor function after stroke.
Methods:
A PRISMA systematic search was conducted for randomized controlled trials. Two authors independently extracted data, and the quality of included studies was assessed.
Results:
Ten studies were included in the current review. DS-NIBS demonstrated a significant effect on upper extremity motor function impairment. However, only two studies showed no clear effects of DS-tDCS on upper extremity motor function after stroke. Due to the limited number of studies, the effects of DS-NIBS remain inconclusive.
Finding:
This review found evidence for the relatively higher efficacy of DS-NIBS on post-stroke upper extremity motor function impairment, compared to the sham and SS-NIBS. Additionally, DS-TMS was found to generate better improvement than DS-tDCS.
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