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Long-Term Outcomes of Stereotactic Radiosurgery for Pineocytomas: An International Multicenter Study
Andréanne Hamel1, Jean-Nicolas Tourigny1, Ajay Niranjan2
1Service de neurochirurgie, Centre de recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke , Québec , Canada.
Neurosurgery
|November 7, 2024
Summary
Stereotactic radiosurgery (SRS) offers a safe and effective treatment for pineocytomas, achieving high rates of long-term tumor control. This approach is a viable alternative to surgery for selected patients with these grade 1 tumors.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Pineocytomas are benign, grade 1 tumors originating from the pineal parenchyma.
- While gross total resection can offer a cure, it carries potential morbidity.
- This study evaluates stereotactic radiosurgery (SRS) for pineocytomas using multi-institutional data.
Purpose of the Study:
- To assess the safety and efficacy of stereotactic radiosurgery (SRS) for managing pineocytomas.
- To provide multi-institutional data on SRS outcomes for these tumors.
- To compare SRS outcomes based on its use as a primary, adjuvant, or recurrent treatment.
Main Methods:
- Data from 38 patients with histology-confirmed grade 1 pineocytomas treated with SRS were collected from the International Radiosurgery Research Foundation.
- Patients required at least 6 months of clinical and imaging follow-up.
- Treatment details included median margin dose (15 Gy) and median treatment volume (3.35 cc).
Main Results:
- Local tumor control was achieved in 92% of patients, with a mean progression-free survival of 21.6 years.
- Tumor control was significantly better when SRS was the primary treatment (P = .016).
- Adverse radiation effects were transient and observed in 11% of patients; 13% died from tumor progression, with larger tumor volume correlating with increased mortality risk.
Conclusions:
- Stereotactic radiosurgery (SRS) is a safe and effective treatment modality for pineocytomas.
- Long-term tumor control is achievable in the majority of patients.
- SRS presents a valuable alternative to surgical resection for select patients.
