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Updated: Jun 8, 2025
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Author Spotlight: Exploring Cellular Zinc Regulation Through ZnT1 Functionality
Published on: June 2, 2023
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Zinc and its binding proteins: essential roles and therapeutic potential
Despoina P Kiouri1,2, Christos T Chasapis3, Thomas Mavromoustakos2
1Institute of Chemical Biology, National Hellenic Research Foundation, 11635, Athens, Greece.
Archives of Toxicology
|November 7, 2024
Summary
Zinc is a vital trace element crucial for growth, immune function, and over 300 enzymes. Understanding zinc
Area of Science:
- Biochemistry
- Cell Biology
- Human Physiology
Background:
- Zinc is an essential micronutrient vital for numerous cellular processes.
- It plays catalytic, structural, and regulatory roles, acting as a cofactor for over 300 enzymes.
- Zinc deficiency is linked to oxidative stress, inflammation, and diseases like cancer and neurological disorders.
Purpose of the Study:
- To review and update the understanding of zinc's biological roles.
- To highlight the implications of zinc deficiency on health.
- To explore zinc's functions in immune regulation, cellular growth, and neurological health.
Main Methods:
- Literature review of zinc biology.
- Analysis of zinc's involvement in physiological processes.
- Examination of zinc homeostasis and deficiency impacts.
Main Results:
- Zinc is indispensable for normal growth and physiological functions.
- Over 3000 proteins require zinc, impacting cell division, immune function, and tissue maintenance.
- Zinc-binding proteins are key to maintaining cellular zinc homeostasis.
Conclusions:
- Zinc is fundamental to numerous biological processes, including immune and neurological health.
- Zinc deficiency contributes to disease pathogenesis.
- Further research is needed to explore zinc supplementation's therapeutic potential.
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