Retinal vasculature changes in patients with internal carotid artery stenosis
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View abstract on PubMed
Summary
This summary is machine-generated.Patients with moderate internal carotid artery (ICA) stenosis show reduced retinal vascular density and choroidal thickness. This study highlights the link between ICA stenosis severity and changes in ocular vasculature.
Area Of Science
- Ophthalmology
- Neurology
- Vascular Biology
Background
- Internal carotid artery (ICA) stenosis can affect cerebral blood flow.
- Retinal vasculature changes may serve as an indicator of systemic vascular health.
Purpose Of The Study
- To evaluate retinal vasculature in patients with ICA stenosis.
- To determine the association between ICA stenosis severity and retinal vasculature alterations.
Main Methods
- Prospective study of 75 subjects: 25 healthy, 25 with 1-49% ICA stenosis, 25 with 50-69% ICA stenosis.
- Ophthalmic examinations including visual acuity, intraocular pressure (IOP), and anterior/posterior segment assessment.
- Optic coherence tomography angiography (OCTA) to measure macular capillary density, optic nerve head capillary density, and choroidal thickness.
Main Results
- Significant differences observed across groups in superficial, deep, and radial peripapillary capillary density, and choroid thickness (p < 0.05).
- Group with 50-69% ICA stenosis showed significantly lower superficial and deep capillary density compared to controls (p < 0.05).
- Subfoveal choroidal thickness was significantly reduced in the moderate stenosis group versus both other groups (p < 0.05).
Conclusions
- Moderate ICA stenosis is associated with decreased density of superficial, deep, and radial peripapillary capillaries.
- Subfoveal choroidal thickness is reduced in patients with moderate ICA stenosis compared to healthy individuals.
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