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Basics of Multivariate Analysis in Neuroimaging Data
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A Comparative Evaluation of Large Language Model Utility in Neuroimaging Clinical Decision Support.

Luke Miller1, Peter Kamel2, Jigar Patel3

  • 1Department of Radiology, University of Maryland Medical Center, Baltimore, MD, USA. Luke.Miller@umm.edu.

Journal of Imaging Informatics in Medicine
|November 7, 2024
PubMed
Summary

Large language models (LLMs) were evaluated for their ability to provide optimal neuroradiology imaging recommendations. GPT-4 and ChatGPT demonstrated superior performance compared to other models like Bard and Llama 2.

Keywords:
BardChatGPTGPT4Imaging utilizationLLM

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Area of Science:

  • Medical Imaging
  • Artificial Intelligence
  • Radiology

Background:

  • Increasing imaging utilization raises concerns about appropriateness in clinical scenarios.
  • Large language models (LLMs) offer potential as accessible resources for healthcare providers.
  • The performance of LLMs in generating medical imaging recommendations is understudied.

Purpose of the Study:

  • To evaluate and compare the appropriateness and usefulness of imaging recommendations from eight LLMs.
  • To assess LLM performance in response to common neuroradiology clinical scenarios.
  • To identify the most effective LLMs for guiding optimal medical image ordering.

Main Methods:

  • Twenty-four neuroradiology clinical scenarios were used to query eight LLMs (ChatGPT, GPT-4, Bard v1/v2, Bing Chat, Llama 2, Perplexity, Claude).
  • Queries assessed LLM ability to provide accurate, actionable advice on optimal image ordering.
  • Recommendations were graded by neuroradiologists against ACR Appropriateness Criteria and New Orleans Head CT Criteria.

Main Results:

  • GPT-4 achieved the highest appropriateness rate (23/24), followed by ChatGPT (20/24), Perplexity (19/24), and Claude (19/24).
  • Llama 2 (5/24) and Bard v1 (13/24) showed lower appropriateness rates.
  • GPT-4 and ChatGPT generally outperformed Bard, Bing Chat, and Llama 2 in providing optimal recommendations.

Conclusions:

  • LLMs show variable performance in providing appropriate neuroradiology imaging recommendations.
  • GPT-4 and ChatGPT are promising tools for assisting with medical imaging decisions.
  • Further research is needed to refine LLMs for clinical decision support in radiology.