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Anxiety, depression and acromegaly: a systematic review
Orlando Silvestro1, Trine Lund-Jacobsen2, Francesco Ferraù3
1Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Journal of Endocrinological Investigation
|November 7, 2024
Summary
Patients with acromegaly frequently experience anxiety and depression, impacting their quality of life. Early detection of these psychological symptoms is crucial for integrated interventions and improved well-being.
Area of Science:
- Endocrinology
- Psychiatry
- Medical Psychology
Background:
- Psychopathology is linked to various medical conditions.
- Acromegaly, a rare endocrine disorder, presents unique psychological features.
- Understanding these features is vital for patient care.
Purpose of the Study:
- To investigate the primary psychopathological outcomes in acromegaly patients.
- To specifically examine the prevalence of anxiety and depression in this population.
Main Methods:
- A systematic literature search was conducted in January 2024.
- Databases searched included PubMed, Scopus, Web of Science, and PsycInfo.
- Keywords focused on acromegaly, anxiety, depression, and alexithymia, adhering to PRISMA guidelines.
Main Results:
- Fifty-five studies met the inclusion criteria.
- Anxiety and depression were prevalent in acromegaly patients, with varying rates.
- Alexithymia was not reported; symptoms did not significantly differ from other chronic conditions but were linked to lower HR-QoL, comorbidities, and disease duration.
Conclusions:
- Anxiety and depression are significant concerns for acromegaly patients, affecting health-related quality of life (HR-QoL).
- Further evaluation of psychological features in acromegaly is warranted.
- Early identification of psychological symptoms can facilitate interventions to enhance patient well-being and HR-QoL.
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