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Inflammation

Inflammation

Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...

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Related Experiment Video

Updated: Jun 8, 2025

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

Endothelial inflammation: how many bad apples?

Michael J Simmonds¹

¹Griffith University.

|November 7, 2024

Summary

No abstract available in PubMed .

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Last Updated: Jun 8, 2025

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

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