Predicting analog intrusions from neural correlates of immediate and lasting effects of cognitive reappraisal

Emotional dysregulation is considered as an etiologically relevant factor for posttraumatic stress disorder. The relevance of immediate and lasting effects of cognitive reappraisal, a prominent emotion regulation strategy, and its habitual use for the development of posttraumatic stress symptoms in response to an experimental trauma are therefore investigated in our study. Eighty-five healthy women participated in a functional magnetic resonance imaging study, which included an emotion regulation paradigm prior to the conduction of the trauma film paradigm, which was used to assess the development of analog intrusions. During the first phase of the emotion regulation paradigm, participants were instructed to use two reappraisal tactics (reinterpretation and distancing) to reduce negative feelings toward aversive pictures or to passively watch aversive and neutral pictures. One week later, these pictures were presented again during a passive reexposure phase. Ratings of negative feelings and blood oxygen level dependent responses in regions of interest served as main outcome variables. The habitual use of cognitive reappraisal was assessed by questionnaire. Reduced habitual use and stronger lasting effects of cognitive reappraisal, as indicated by reduced insula activation during reexposure to pictures previously reinterpreted and distanced from, predicted the development of long-term analog intrusions. Stronger lasting effects of both reappraisal tactics for women with long-term analog intrusions seem to result from stronger emotional reactivity processes. Women with long-term analog intrusions in response to an experimental trauma seem to benefit to a greater extent from a cognitive reappraisal training than women without long-term intrusions. (PsycInfo Database Record (c) 2025 APA, all rights reserved).