Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Generation of bound states in the continuum via geometric stretching of plasmonic moiré superlattices.

Optics express·2026
Same author

Molecular dynamics simulation of FOX-7 decomposition reaction under high temperature and pressure.

Journal of molecular modeling·2025
Same author

Cell-free recombinase-integrated Boolean output system.

Cell systems·2025
Same author

Constraint-Based Sub-Graph Partitioning for Multi-Cellular Biological Networks.

IEEE transactions on computational biology and bioinformatics·2025
Same author

Improving engineered biological systems with electronics and microfluidics.

Nature biotechnology·2025
Same author

Component library creation and pixel array generation with micromilled droplet microfluidics.

Microsystems & nanoengineering·2025

Related Experiment Video

Updated: Jun 8, 2025

Fluorescence detection methods for microfluidic droplet platforms
14:16

Fluorescence detection methods for microfluidic droplet platforms

Published on: December 10, 2011

22.1K

Integrated Real-Time CMOS Luminescence Sensing and Impedance Spectroscopy in Droplet Microfluidics.

Qijun Liu, Diana Arguijo Mendoza, Alperen Yasar

    IEEE Transactions on Biomedical Circuits and Systems
    |November 7, 2024
    PubMed
    Summary

    This study introduces a novel microfluidic system with custom integrated circuits for rapid, high-throughput biosensor screening. The platform enhances flexibility, scalability, and cost-efficiency in detecting biological and chemical targets.

    More Related Videos

    Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers
    10:21

    Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers

    Published on: May 5, 2016

    10.5K
    Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
    11:54

    Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

    Published on: March 13, 2017

    9.2K

    Related Experiment Videos

    Last Updated: Jun 8, 2025

    Fluorescence detection methods for microfluidic droplet platforms
    14:16

    Fluorescence detection methods for microfluidic droplet platforms

    Published on: December 10, 2011

    22.1K
    Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers
    10:21

    Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers

    Published on: May 5, 2016

    10.5K
    Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
    11:54

    Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

    Published on: March 13, 2017

    9.2K

    Area of Science:

    • Biotechnology and Biomedical Engineering
    • Microfluidics and Lab-on-a-Chip Technology
    • Biosensor Development and Applications

    Background:

    • High-throughput biosensor screening is crucial for health and environmental monitoring.
    • Traditional methods are labor-intensive, low-throughput, and inefficient for large-scale screening.
    • Existing techniques struggle with diverse environmental and chemical conditions.

    Purpose of the Study:

    • To develop a modular droplet microfluidic system for advanced biosensor screening and optimization.
    • To integrate custom CMOS integrated circuits (ICs) for impedance spectroscopy and bioluminescence detection.
    • To overcome the limitations of traditional biosensor testing methods.

    Main Methods:

    • Development of a modular droplet microfluidic system.
    • Fabrication of custom CMOS ICs for impedance spectroscopy and bioluminescence detection (65 nm process).
    • Demonstration of sensing luciferase enzyme-substrate reactions in nanoliter (nL)-volume droplets.

    Main Results:

    • CMOS ICs enable efficient droplet detection and analysis.
    • Impedance spectroscopy chip detects 4 nL droplets at 67 mm/s with 45 pA resolution.
    • Luminescence detector senses optical signals from 38 nL droplets with 6.7 nA/count resolution.
    • Real-time concurrent use of both detection methods for cross-validation.

    Conclusions:

    • The developed hybrid microfluidic platform significantly advances biosensor testing.
    • The system offers increased flexibility, scalability, and cost-efficiency.
    • Enables rapid and accurate detection of biological and chemical targets.