[Metastatic pituitary lesion]

Area of Science:

• Endocrinology
• Neurosurgery
• Oncology

Background:

• Pituitary metastases are rare, affecting 1.8-4% of cases.
• Management demands a multidisciplinary approach.
• These lesions present diagnostic and therapeutic challenges.

Purpose of the Study:

• To report on three cases of pituitary metastases treated surgically.
• To discuss the clinical presentation, management, and outcomes.
• To highlight the complexity of treating metastatic pituitary lesions.

Main Methods:

• Case series of three patients with pathomorphologically confirmed pituitary metastases.
• Neurosurgical intervention at the National Research Center of the National Research Institute of Endocrinology.
• Follow-up assessment of disease progression and patient condition.

Main Results:

• Primary tumors included breast cancer, lung carcinoid, and clear cell kidney cancer.
• All patients exhibited panhypopituitarism, chiasmal syndrome, and mass effect.
• Two patients experienced disease progression, one receiving further radiotherapy; one patient remained stable.

Conclusions:

• Neurosurgical treatment is a viable option for pituitary metastases.
• Outcomes vary, with potential for disease progression despite treatment.
• Multidisciplinary collaboration is crucial for optimal patient management.