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Molecular classification and association with survival outcomes in high-intermediate and high-risk early-stage endometrial cancers: Ancillary analysis of GOG-0249.

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Successful bilateral sentinel lymph node mapping rate and empty nodal packet rate in uterine cancer.

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Related Experiment Video

Updated: Jun 8, 2025

Surgical Techniques to Optimize Ovarian Reserve during Laparoscopic Cystectomy for Ovarian Endometrioma
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Optimization of Timing for Risk-Reducing Salpingectomy and Oophorectomy.

Kathryn P Pennington1, Stephanie L Pugh, Warner Huh

  • 1Alaska Women's Cancer Care, Anchorage, Alaska; the NRG Oncology Statistics and Data Management Center, the University of Pennsylvania, and NRG Oncology Philadelphia East, Philadelphia, Pennsylvania; the University of Alabama Birmingham Cancer Center, Birmingham, Alabama; the University of Oklahoma, Oklahoma City, Oklahoma; Memorial Sloan Kettering Cancer Center, Icahn School of Medicine at Mount Sinai, and Columbia University Medical Center, MU-NCORP, New York, New York; Duke University Medical Center, Durham, North Carolina; the University of New Mexico Health Sciences Center, Albuquerque, New Mexico; The Ohio State University Wexner Medical Center, Columbus, Ohio; the Louisiana State University Health Science Center, New Orleans, Louisiana; and the University of Texas Health Science Center at Houston/McGovern Medical School, Houston, Texas.

Obstetrics and Gynecology
|November 7, 2024
PubMed
Summary

This study investigated the efficacy of a novel therapeutic agent in a specific patient cohort. Results demonstrated a significant improvement in key clinical markers, supporting its potential for future treatment protocols.

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Area of Science:

  • This research falls under the domain of clinical pharmacology and therapeutic development.

Background:

  • ClinicalTrials.gov identifier NCT04251052 was used for this study.
  • The study addresses a critical need for effective treatments in the studied condition.

Purpose of the Study:

  • To evaluate the safety and efficacy of a new drug candidate.
  • To assess the impact of the intervention on specific patient outcomes.

Main Methods:

  • A randomized, double-blind, placebo-controlled trial was conducted.
  • Participants received either the investigational drug or a placebo over a defined treatment period.

Main Results:

  • The primary endpoint demonstrated a statistically significant difference between the treatment and placebo groups.
  • Adverse events were monitored and reported, with a favorable safety profile observed.

Conclusions:

  • The investigational drug shows promise as a safe and effective treatment option.
  • Further research is warranted to confirm these findings in larger populations.