Long-term outcomes of nodal surveillance practices in sentinel node positive melanoma: An early post MSLT-II cohort
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View abstract on PubMed
Summary
This summary is machine-generated.Nodal surveillance is a viable management strategy for sentinel lymph node-positive melanoma, showing outcomes comparable to clinical trial data. This approach offers feasible melanoma management following the MSLT-II trial findings.
Area Of Science
- Melanoma Research
- Surgical Oncology
- Clinical Outcomes
Background
- The MSLT-II trial (2017) established equivalent melanoma survival between nodal surveillance and completion lymph node dissection for sentinel lymph node-positive melanoma.
- This study assesses real-world outcomes of nodal surveillance in an early post-MSLT-II cohort.
Purpose Of The Study
- To evaluate the effectiveness and recurrence rates of nodal surveillance in sentinel lymph node-positive melanoma patients.
- To compare institutional outcomes with established clinical trial findings.
Main Methods
- Retrospective analysis of 212 patients managed with nodal surveillance from 2017-2023.
- Kaplan-Meier curves and Cox proportional hazard models analyzed recurrence-free survival.
- Primary outcomes included nodal basin and any-site recurrence.
Main Results
- Median follow-up was 23 months; 29.7% of patients experienced recurrence.
- Three-year recurrence-free survival rates were 58.3% for any site and 80.9% for nodal basin.
- Older age and head/neck primary sites were associated with worse recurrence-free survival.
Conclusions
- Nodal surveillance demonstrates feasible and comparable long-term outcomes to clinical trial data for sentinel lymph node-positive melanoma.
- This management strategy remains a practical option for selected melanoma patients.
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