Related Experiment Video

Updated: Jun 8, 2025

CIRCLE-Seq for Interrogation of Off-Target Gene Editing
08:23

CIRCLE-Seq for Interrogation of Off-Target Gene Editing

Published on: November 1, 2024

531

Seed sequences mediate off-target activity in the CRISPR-interference system

Neha Rohatgi1, Jean-Philippe Fortin2, Ted Lau3

  • 1Genentech Computational Sciences, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA; Roche Informatics, Hoffman-La Roche Canada, 7070 Mississauga Road, Mississauga, ON, Canada.

Cell Genomics
|November 7, 2024
PubMed

Keywords:
CRISPR activationCRISPR interferencePAM-proximal seed sequenceoff-target activity

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