Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Meiosis vs. Mitosis02:57

Meiosis vs. Mitosis

53.0K
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
53.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Germinal vesicle oocytes' rescue: a worthless treatment or a patient-centred approach? Eight years of clinical experience in poor prognosis patients.

Human reproduction (Oxford, England)·2026
Same author

Timing matters: molecular signatures linked to developmental and implantation processes in D5 and D6 blastocysts.

F&S science·2026
Same author

To discard or to not discard 2.1PN? A systematic review and evidence table analysis.

Journal of assisted reproduction and genetics·2026
Same author

Another round, another chance: oocyte developmental competence and outcomes in second IVF attempts-the earlier, the better.

Journal of assisted reproduction and genetics·2026
Same author

Exploring the Association Between Gut Microbiota and Infertility in Women with Multiple Implantation Failures: An Exploratory Study.

Microorganisms·2026
Same author

Intermediate copy number and clinical utility in embryo selection (reply to letter-to-the-editor).

American journal of obstetrics and gynecology·2026

Related Experiment Video

Updated: Jun 8, 2025

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos
11:25

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

Published on: February 22, 2016

10.8K

Human embryos with segmental aneuploidies display delayed early development: a multicenter morphokinetic analysis.

Matteo Figliuzzi1, Lorena Bori2, Christian Simon Ottolini3

  • 1Juno Genetics Italy, Reproductive Genetics, Rome, Italy.

Fertility and Sterility
|November 7, 2024
PubMed
Summary

Segmental aneuploid embryos show slower early development compared to euploid embryos. Morphokinetic analysis combined with morphological features can aid in identifying these embryos during preimplantation genetic testing.

Keywords:
PGT-ASegmental aneuploidyembryologymorphokineticstime-lapse

More Related Videos

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
00:09

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

9.3K
Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation
12:59

Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation

Published on: February 28, 2021

3.6K

Related Experiment Videos

Last Updated: Jun 8, 2025

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos
11:25

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

Published on: February 22, 2016

10.8K
Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
00:09

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

9.3K
Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation
12:59

Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation

Published on: February 28, 2021

3.6K

Area of Science:

  • Embryology
  • Genetics
  • Reproductive Medicine

Background:

  • Preimplantation genetic testing for aneuploidy (PGT-A) is crucial for improving IVF outcomes.
  • Segmental aneuploidies, unlike whole-chromosome aneuploidies, can arise from complex chromosomal rearrangements.
  • Understanding morphokinetic patterns of segmental aneuploid embryos is essential for accurate embryo selection.

Purpose of the Study:

  • To investigate unique morphokinetic patterns in segmental aneuploid embryos.
  • To assess the predictive capability of morphokinetic data for identifying segmental aneuploidies.

Main Methods:

  • A retrospective multicenter study analyzed 7,027 embryos using time-lapse systems.
  • Morphokinetic features were compared between euploid, whole-chromosome aneuploid, and segmental aneuploid embryos.
  • Logistic regression models incorporating morphokinetic and morphological features were developed and validated.

Main Results:

  • Segmental aneuploid embryos exhibited significantly slower cleavage rates in early cell cycles compared to euploid and whole-chromosome aneuploid siblings.
  • A logistic model using multicenter data showed modest predictive performance (test-AUROC = 0.57).
  • Incorporating multinucleation and blastomere exclusion improved prediction accuracy (train-AUROC = 0.71).

Conclusions:

  • Morphokinetic analysis, especially when combined with morphological features, can help identify segmental aneuploid embryos.
  • The developed predictive framework may assist in decision-making during PGT-A cycles.
  • Further research with comprehensive annotation systems is warranted to refine embryo evaluation.