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Published on: February 10, 2015
Systemic immune-inflammatory index and platelet-to-lymphocyte ratio in intrahepatic cholestasis of pregnancy
Nihal Çallıoğlu1, Güray Tuna1, Özden Tandoğan1
1From the Department of Perinatology (Çallıoğlu, Tuna, Ersan, Bilirer), Başakşehir Çam and Sakura City Hospital, from the Department of Perinatology (Çallıoğlu), Gaziosmanpasa Training and Research Hospital, from the Department of Nursing (Tandoğan), Faculty of Health Sciences, Istanbul Arel University, Istanbul, and from the Department of Perinatology (Atalay), Ordu Training and Research Hospital, Ordu, Turkey.
Objectives:
To investigate the role of systemic immune-inflammation index (SII) in the diagnosis and severity of intrahepatic cholestasis of pregnancy (ICP).
Methods:
This case-control research involved 173 pregnant women with ICP and 266 gestational age-related healthy pregnant women as the control group. Criteria for diagnosing ICP were acceptance of increased serum total bile acid (TBA) levels (≥10 μmol/L). The mild ICP group (n=109) had TBA levels ranging between 10-39 µmol/l, while the severe ICP group (n=64) had a minimum TBA level above 40 µmol/l. Sociodemographic data, laboratory results, and SII values were compared between groups. Cut-off values were calculated to predict ICP. The SII was calculated as the platelet count × neutrophil count/lymphocyte count.
Results:
The leukocyte and neutrophil counts were lower (p<0.01), and the monocyte count was higher (p=0.026) in the severe ICP group compared to the controls. The platelet-to-lymphocyte ratio (PLR) was higher in mild ICP groups than in controls (p<0.01). The optimum PRL cut-off value was 126.2238, with a sensitivity of 57.2% and specificity of 57.1%.
Conclusion:
Elevated SII values support the evidence for the inflammatory properties of ICP but do not aid in diagnosing and determining its severity. Platelet-to-lymphocyte ratio may be a useful marker in determining ICP.
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