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  1. Home
  3. Bola Family Genes Are The Drivers And Potential Biomarkers Of Survival In Kidney Renal Clear Cell Carcinoma Patients.
  1. Home
  3. Bola Family Genes Are The Drivers And Potential Biomarkers Of Survival In Kidney Renal Clear Cell Carcinoma Patients.

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BOLA family genes are the drivers and potential biomarkers of survival in kidney renal clear cell carcinoma patients.

Mohammed Alissa1, Abdullah Alghamdi1, Suad A Alghamdi1

  • 1From the Department of Medical Laboratory (Alissa, A. Alghamdi, S. A. Alghamdi, Alshehri), College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, from the Department of Clinical Laboratory Sciences (Alsuwat, Allahyani), College of Applied Medical Sciences, Taif University, Taif, and from the Department of Clinical Laboratory Sciences (Alkhathami), College of Applied Medical Sciences, King Khalid University, Abha, Kingdom of Saudi Arabia.

Saudi Medical Journal
|November 7, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

The BOLA gene family, including BOLA1, BOLA2, and BOLA3, shows significant changes in kidney renal clear cell carcinoma (KIRC). High expression of these BOLA genes correlates with poorer survival, suggesting their potential as diagnostic and prognostic markers for KIRC.

Keywords:
BOLA genescarcinomagene expression regulationmolecular targeted therapyprognostic biomarkers

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Kidney renal clear cell carcinoma (KIRC) is a significant health concern.
  • The role of the BOLA gene family in KIRC pathogenesis requires further elucidation.

Purpose of the Study:

  • To investigate the diagnostic and prognostic value of the BOLA gene family in KIRC.
  • To explore the relationship between BOLA gene expression, methylation, and patient outcomes in KIRC.

Main Methods:

  • In silico analysis using TCGA-KIRC cohorts and cBioPortal.
  • In vitro experiments involving gene silencing in KIRC cell lines.
  • Analysis of tumor-immune interactions and survival data.

Main Results:

  • BOLA1, BOLA2, and BOLA3 were significantly upregulated and hypomethylated in KIRC cell lines and tissues.
  • High expression of BOLA genes correlated with shorter overall and relapse-free survival in KIRC patients.
  • Gene silencing of BOLA genes reduced KIRC cell growth and proliferation.

    • Conclusions:

    • The BOLA gene family holds potential as diagnostic and prognostic biomarkers for KIRC.
    • BOLA genes may represent novel therapeutic targets for KIRC treatment.
    • Understanding BOLA gene function offers insights into KIRC progression and immune interactions.