Palladium Catalyzed Cyanation of Diaryl Sulfoxides
Xianchao Qiu1, Guangcai Qu1, Benqiang Cui1
1School of Chemistry and Material Science and Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou 221116, China.
Abstract:
Aryl nitriles are highly versatile and useful compounds. A palladium-catalyzed cyanation of diaryl sulfoxides using bench-stable Zn(CN)2 as the cyanating reagent has been developed. The reaction proceeded well using Pd(OAc)2 as the catalyst with the inexpensive ligand PCy3 in the presence of t-BuONa. The method has a broad scope of substrates and is scalable. The regioselective cyanation of unsymmetrical diaryl sulfoxides was observed at the side of electron-deficient and more steric hindered aryl groups.
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