Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Psychological and Sociocultural Causes of Schizophrenia

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...

Biological Causes of Schizophrenia

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Passage of Time or Delay Signal at the Level of Milliseconds: A New Approach and a Selective Difficulty in Individuals With Schizophrenia.

Schizophrenia bulletin·2026

Same author

Seeing elephants and drinking water from a porcelain vase - A case of septin-7 antibody-associated encephalitis presenting as a severe disorganized psychosis.

Translational psychiatry·2026

Same author

Secondary obsessive-compulsive syndromes: a systematic literature review resulting in 228 suspected cases.

Molecular psychiatry·2025

Same author

Localization of Realistic Spatial Patches of Complex Source Activity in MEG and EEG.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2025

Same author

Cortical gyrification predicts initial treatment response in adults with ADHD.

Translational psychiatry·2025

Same author

Bodily Self-Disturbances and Hallucinations in Schizophrenia.

Schizophrenia bulletin·2025

Search research articles

Related Experiment Video

Updated: Jun 8, 2025

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies

Published on: May 9, 2019

Do smaller P300 amplitudes in schizophrenia result from larger variability in temporal processing?

Mareike Wilson^1,2,3,4, Ellen Joos^1,2,3,5, Anne Giersch⁵

¹Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Freiburg, Germany.

Schizophrenia (Heidelberg, Germany)

|November 7, 2024

Summary

Reduced P3b amplitudes in schizophrenia patients are linked to temporal imprecision in neural activity, not just reduced power. This highlights the critical role of precise timing in brain function for individuals with schizophrenia.

More Related Videos

The Joint Effect of Social Comparison and Social Distance on Evaluation of Intertemporal Choice Outcomes in Event-related Potential Studies

The Joint Effect of Social Comparison and Social Distance on Evaluation of Intertemporal Choice Outcomes in Event-related Potential Studies

Published on: August 25, 2023

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

Related Experiment Videos

Last Updated: Jun 8, 2025

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies

Published on: May 9, 2019

The Joint Effect of Social Comparison and Social Distance on Evaluation of Intertemporal Choice Outcomes in Event-related Potential Studies

The Joint Effect of Social Comparison and Social Distance on Evaluation of Intertemporal Choice Outcomes in Event-related Potential Studies

Published on: August 25, 2023

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

Area of Science:

Neuroscience
Psychiatry
Cognitive Science

Background:

The P3b event-related potential (ERP) is often reduced in individuals with schizophrenia.
Temporal imprecision in neural processing is hypothesized to be a key factor in schizophrenia pathophysiology.

Purpose of the Study:

To investigate whether reduced P3b amplitudes in schizophrenia are due to decreased neural activity (power) or impaired temporal precision (inter-trial phase coherence; ITC).
To analyze EEG data from two independent studies using oddball paradigms to assess P3b amplitude and ITC in delta and theta bands.

Main Methods:

Utilized electroencephalography (EEG) data from two separate studies comprising patients with schizophrenia and matched neurotypical controls.
Analyzed event-related potentials (ERPs), specifically the P3b component, and calculated inter-trial phase coherence (ITC) in delta and theta frequency bands.

Main Results:

Both studies confirmed smaller P3b amplitudes in patients with schizophrenia compared to controls.
Reduced ITC in the delta band was observed in patients and correlated significantly with P3b peak amplitudes across all participants.
Study 1 also found reduced theta band ITC in patients, correlating with P3b amplitudes, though this was not replicated in Study 2.

Conclusions:

Reduced P3b amplitude in schizophrenia is associated with diminished temporal precision of neural activity, particularly in the delta band.
These findings underscore the significance of temporal imprecision over reduced neural activity in schizophrenia.
The results contribute to understanding temporal processing deficits and their link to disturbances in the sense of self in schizophrenia.