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Understanding the heterogeneity and dysfunction of HDL in chronic kidney disease: insights from recent reviews

Zhen Xu1, Shuo Yang1, Liyan Cui2

  • 1Peking University Third Hospital, Beijing, China.

BMC Nephrology
|November 7, 2024
PubMed

Insights

High-density lipoprotein (HDL), crucial for cholesterol removal, may lose its protective function in chronic kidney disease (CKD). This review explores HDL changes in CKD, aiming for new therapeutic strategies.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Metabolic Disorders

Background:

  • Chronic kidney disease (CKD) is a global health issue.
  • Dyslipidemia is a common complication in CKD patients.
  • High-density lipoprotein (HDL) plays a key role in reverse cholesterol transport, preventing atherosclerosis.

Purpose of the Study:

  • To review HDL heterogeneity and subclasses in CKD.
  • To examine functional changes of HDL during CKD progression.
  • To explore the therapeutic applications of HDL in CKD treatment.

Main Methods:

  • Literature review focusing on HDL in CKD.
  • Analysis of studies on HDL subclasses and function.
  • Synthesis of current research on HDL-based CKD therapies.

Main Results:

  • HDL function is altered in the CKD internal environment.
  • HDL may exhibit detrimental effects in CKD progression.
  • Understanding HDL changes is crucial for CKD management.

Conclusions:

  • Altered HDL metabolism is a significant aspect of CKD.
  • Further research into HDL's role in CKD can inform new treatments.
  • Targeting HDL may offer novel therapeutic strategies for CKD patients.

Keywords:
Chronic kidney diseaseDyslipidemiaHigh density lipoproteinsSubclasses

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