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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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  11. Sex- And Site-specific Associations Of Circulating Lipocalin 2 And Incident Colorectal Cancer: Results From The Epic Cohort.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Sex- And Site-specific Associations Of Circulating Lipocalin 2 And Incident Colorectal Cancer: Results From The Epic Cohort.

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Sex- and site-specific associations of circulating lipocalin 2 and incident colorectal cancer: Results from the EPIC cohort.

Robin Reichmann1, Katharina Nimptsch2,3, Tobias Pischon2,3,4,5

  • 1Biomarkers and Metabolism Research Group, Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology, Bremen, Germany.

International Journal of Cancer
|November 8, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Elevated lipocalin 2 (LCN2) levels before diagnosis are linked to increased colon cancer risk, especially in women and those with abdominal obesity. This finding highlights LCN2 as a potential biomarker for early colon cancer detection.

Keywords:
EPICcolorectal cancerimmunitylipocalin 2

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Area of Science:

  • Oncology
  • Biomarkers
  • Epidemiology

Background:

  • Lipocalin 2 (LCN2) is a potential biomarker for intestinal inflammation, metabolic homeostasis, and colon carcinogenesis.
  • Human research on LCN2's role in colorectal cancer (CRC) is limited.

Purpose of the Study:

  • To investigate the association between pre-diagnostic circulating LCN2 concentrations and incident CRC.
  • To explore these associations by tumor subsite, sex, and adiposity status.

Main Methods:

  • A nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
  • Measured LCN2 in 1267 CRC cases and 1267 matched controls.
  • Used conditional logistic regression and weighted Cox proportional hazard regression.
metabolism

Main Results:

  • Pre-diagnostic LCN2 was associated with an increased risk of colon cancer (IRR: 1.26 [1.00-1.59]).
  • The association was stronger in women (IRR: 1.66 [1.20-2.30]) and for proximal colon cancer (IRR: 1.96 [1.15-3.34]).
  • A positive association was observed in individuals with high waist circumference, and an inverse association in those with low waist circumference.

Conclusions:

  • Pre-diagnostic LCN2 concentrations are positively associated with colon cancer risk.
  • The association is particularly evident in the proximal colon, in women, and in individuals with abdominal adiposity.
  • LCN2 may serve as a valuable predictive biomarker for colon cancer.