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Related Experiment Videos

Behaviour-associated alopecia areata in mice.

K Militzer, E Wecker

    Laboratory Animals
    |January 1, 1986
    PubMed
    Summary

    Male mice housed with C57BL females developed hair loss, primarily on the head. This hair loss is linked to increased grooming behaviors by female mice, suggesting a genetic component to this phenomenon.

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    Area of Science:

    • Veterinary Dermatology
    • Animal Behavior
    • Genetics

    Background:

    • Alopecic lesions are observed in laboratory mice.
    • Hair loss in male mice can impact research findings and animal welfare.

    Purpose of the Study:

    • To investigate the cause of alopecia in male mice housed with female mice.
    • To determine if grooming behavior contributes to hair loss.
    • To explore potential genetic factors influencing this phenomenon.

    Main Methods:

    • Observation of five different mouse strains.
    • Time-lapse photography to record animal behavior.
    • Examination of lesion location and frequency.

    Main Results:

    • Alopecia was most common in male breeding mice housed with C57BL females.
    • Lesions occurred primarily on the head, shoulders, back, and pelvic regions.
    • Increased self-grooming in males and significantly increased allogrooming by females were observed.
    • The frequency of lesions was higher in males housed with C57BL females.

    Conclusions:

    • Female mice, particularly C57BL strain, exhibit increased grooming behavior towards male partners, leading to alopecia.
    • This increased grooming activity appears to be genetically determined.
    • Understanding these behavioral and genetic factors is crucial for mouse model research and welfare.

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