Relationship between serum omentin-1 levels and nascent metabolic syndrome in Caucasian patients with obesity
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View abstract on PubMed
Summary
This summary is machine-generated.Omentin-1 levels are lower in individuals with metabolic syndrome (MS). Lower omentin-1 correlates with increased adiposity, insulin resistance, and triglycerides, suggesting its role in MS development.
Area Of Science
- Endocrinology
- Metabolic Research
- Obesity Studies
Background
- Metabolic syndrome (MS) is a growing health concern.
- Omentin-1, an adipokine, is implicated in metabolic regulation.
- The relationship between omentin-1 and early-stage MS requires further elucidation.
Purpose Of The Study
- To investigate the association between serum omentin-1 levels and nascent metabolic syndrome in obese subjects.
- To identify predictors of metabolic syndrome in this population.
Main Methods
- A cross-sectional study involving 606 obese individuals.
- Assessment of adiposity, blood pressure, glucose metabolism (including HOMA-IR and TyG index), lipid profile, C-reactive protein, and serum omentin-1.
- Statistical analysis to determine correlations and predictors of MS.
Main Results
- Subjects without MS exhibited significantly higher omentin-1 levels compared to those with MS.
- Omentin-1 showed inverse correlations with adiposity parameters, glucose, insulin, HOMA-IR, TyG index, and triglycerides.
- Omentin-1 demonstrated a positive correlation with HDL-cholesterol.
- Obesity (BMI), insulin resistance (HOMA-IR), and serum omentin-1 were identified as independent predictors of MS.
- A serum omentin-1 cut-off of 372.45 ng/ml was determined for MS prediction.
Conclusions
- Obese Caucasian individuals with nascent MS present with reduced serum omentin-1 levels.
- Serum omentin-1 levels are inversely associated with key metabolic syndrome components, including insulin resistance and triglycerides.
- Omentin-1 may serve as a potential biomarker for early detection of metabolic syndrome in obese populations.
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