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Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
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F2-Isoprostanes Are Associated With Increased Fracture Risk in Type 2 Diabetes.

Bowen Wang1,2, Ruban Dhaliwal3,4, Susan K Ewing5

  • 1Rensselaer-Icahn School of Medicine at Mount Sinai Center for Engineering and Precision Medicine, New York, NY 10019, USA.

The Journal of Clinical Endocrinology and Metabolism
|November 8, 2024
PubMed
Summary
This summary is machine-generated.

Oxidative stress, measured by plasma F2-isoprostanes, significantly increases fracture risk in older adults with type 2 diabetes (T2D). This association is independent of bone mineral density, highlighting a key factor in T2D-related bone fragility.

Keywords:
F2-isoprostanesfracture riskoxidative stresstype 2 diabetes

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Area of Science:

  • Gerontology
  • Endocrinology
  • Biochemistry

Background:

  • Type 2 diabetes (T2D) is linked to higher fracture risk, even with normal bone mineral density (BMD).
  • Increased oxidative stress in T2D may contribute to bone fragility and diabetic complications.

Purpose of the Study:

  • To determine if plasma F2-isoprostanes, a marker of oxidative stress, correlate with incident fracture risk in older adults with diabetes.
  • To investigate the relationship between oxidative stress markers and fracture risk in the context of T2D.

Main Methods:

  • An observational cohort study analyzed data from the Health, Aging, and Body Composition study.
  • Older adults (70-79 years) with (N=132) and without (N=571) T2D were included, with baseline plasma F2-isoprostanes measurements.
  • Incident clinical fractures served as the primary outcome measure.

Main Results:

  • Higher plasma F2-isoprostanes levels were significantly associated with a 93% increased risk of incident clinical fractures in the T2D group (HR: 1.93, p=0.002).
  • No significant association between F2-isoprostanes and fracture risk was observed in the non-diabetes group (HR: 0.98, p=0.79).
  • In T2D, F2-isoprostanes correlated with decreased total hip BMD over time, but not with glycoxidation or bone turnover markers.

Conclusions:

  • Elevated plasma F2-isoprostanes levels are linked to increased fracture risk in individuals with diabetes.
  • This association is independent of baseline bone mineral density, suggesting oxidative stress is a critical factor in T2D bone fragility.