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Cell components of tumor microenvironment in lung adenocarcinoma: Promising targets for small-molecule compounds
Mingyu Han1, Feng Wan2,3, Bin Xiao4
1Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, China.
Abstract:
Lung cancer is one of the most lethal tumors in the world with a 5-year overall survival rate of less than 20%, mainly including lung adenocarcinoma (LUAD). Tumor microenvironment (TME) has become a new research focus in the treatment of lung cancer. The TME is heterogeneous in composition and consists of cellular components, growth factors, proteases, and extracellular matrix. The various cellular components exert a different role in apoptosis, metastasis, or proliferation of lung cancer cells through different pathways, thus contributing to the treatment of adenocarcinoma and potentially facilitating novel therapeutic methods. This review summarizes the research progress on different cellular components with cell-cell interactions in the TME of LUAD, along with their corresponding drug candidates, suggesting that targeting cellular components in the TME of LUAD holds great promise for future theraputic development.
Insights
This review explores the tumor microenvironment (TME) in lung adenocarcinoma (LUAD). Targeting cellular components within the LUAD TME shows promise for developing new lung cancer therapies.
Area of Science:
- Oncology
- Cancer Biology
- Immunology
Background:
- Lung cancer, particularly lung adenocarcinoma (LUAD), has a poor 5-year survival rate (<20%).
- The tumor microenvironment (TME) is a critical factor in LUAD progression and treatment resistance.
- The TME comprises diverse cellular and non-cellular components influencing cancer cell behavior.
Purpose of the Study:
- To review current research on cellular components within the LUAD TME.
- To examine cell-cell interactions and their roles in LUAD.
- To identify potential therapeutic targets and drug candidates within the TME.
Main Methods:
- Literature review of studies on LUAD tumor microenvironment.
- Analysis of cellular components and their interactions.
- Identification of therapeutic strategies targeting TME components.
Main Results:
- Cellular components in the LUAD TME significantly impact cancer cell apoptosis, metastasis, and proliferation.
- Specific cell-cell interactions within the TME are key drivers of LUAD progression.
- Various drug candidates targeting TME cellular components have been identified.
Conclusions:
- Targeting cellular components of the LUAD TME is a promising therapeutic strategy.
- Understanding TME complexity is crucial for effective LUAD treatment development.
- Further research into TME-targeted therapies could improve patient outcomes for lung adenocarcinoma.
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