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Quantification of Atherosclerosis in Mice
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Quantification of Atherosclerosis in Mice

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Apolipoprotein E Gene ε4 Allele is Associated with Atherosclerosis in Multiple Vascular Beds

Youni Lin1, Min Yang1, Qifeng Liu1

  • 1Center for Cardiovascular Diseases, Meizhou People's Hospital, Meizhou, People's Republic of China.

International Journal of General Medicine
|November 8, 2024
PubMed

Insights

The Apolipoprotein E (APOE) ε4 allele is linked to atherosclerosis affecting multiple vascular beds. This finding helps understand risk factors for this systemic vascular disease.

Area of Science:

  • Genetics
  • Cardiovascular Disease
  • Molecular Biology

Background:

  • Atherosclerosis is a systemic disease impacting various blood vessels.
  • Risk factors for atherosclerosis across multiple vascular beds are not well understood.
  • Apolipoprotein E (APOE) plays a role in inflammation and lipid deposition during atherosclerosis.

Purpose of the Study:

  • To investigate the association between Apolipoprotein E (APOE) gene polymorphisms and atherosclerosis in multiple vascular beds.
  • To identify potential genetic markers for predicting the extent of vascular involvement in atherosclerosis.

Main Methods:

  • Compared APOE genotypes in 416 patients with single vascular bed atherosclerosis and 658 patients with multiple vascular bed atherosclerosis.
  • Utilized logistic regression analysis to determine the relationship between APOE genotypes and multi-vascular bed atherosclerosis.
  • Analyzed differences in APOE genotype frequencies between patient groups.

Main Results:

  • The APOE E3/E4 genotype frequency was significantly lower in patients with multiple vascular bed atherosclerosis (11.4%) compared to single vascular bed atherosclerosis (17.8%; P=0.004).
  • Logistic regression revealed that the APOE E3/E4 genotype (OR 0.598, P=0.005) and the APOE ε4 allele (OR 0.630, P=0.010) were associated with a reduced risk of atherosclerosis in multiple vascular beds.
  • No significant differences were observed in demographic factors or traditional risk factors (hypertension, diabetes, smoking) between the groups or across different APOE alleles.

Conclusions:

  • The APOE ε4 allele is associated with atherosclerosis affecting multiple vascular beds.
  • Findings suggest a protective role of the APOE ε4 allele against the development of multi-vascular bed atherosclerosis.
  • Further research is warranted to elucidate the mechanisms underlying this association.
Abstract

Keywords:
APOEatherosclerosismultiple vascular bedspolymorphism

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